Dr. med. Börge Arndt

Curriculum vitae (in extracts)

Work Experience

Studies/Doctoral Thesis

Academic activities

Research and Promotion

• 2009-2013: Research project: Immune system and autoimmunity
• FöFoLe PhD program on the topic: the influence of regulatory CD8+ CD122+ T cells on the pathogenesis of autoimmune diseases in the NOD mouse
• Funding by the Friedrich Baur Foundation on the topic: The influence of regulatory CD8+ CD122+ T cells on the pathogenesis of autoimmune diseases in the NOD mouse
• 2011: Presentation at the DDG congress on the topic: "CD8+ CD122+ PD-1- effector cells promote the development of autoimmunity in NOD mice".
• 2004-2009: Collaboration in the research group of Prof. Schraven and Dr. L. Simeoni University of Magdeburg on the topic: TCR Signaling
• NBL-3 funding program of the state of Saxony-Anhalt

Contributions

• Management of Locally Advanced or Metastatic Combined Hepatocellular Cholangiocarcinoma

Zhao J, Stephan-Falkenau S, Schuler M, Arndt B.

Cancers (Basel). 2023 Feb 3;15(3):988

• Lymphoepitheliale Sialadenitis-artige Thymushyperplasie

Börge Arndt, Timo Gaiser, Alexander Marx, Christina Rieger

DMW 2016; 141(14): 1026-1029

• CD8+ CD122+ PD-1- effector cells promote the development of diabetes in NOD mice.

Arndt B, Witkowski L, Ellwart J, Seissler J.

J Leukoc Biol. 2015 Jan;97(1):111-20

• TCR activation kinetics and feedback regulation in primary human T cells.

Poltorak M, Arndt B, Kowtharapu BS, Reddycherla AV, Witte V, Lindquist JA, Schraven B,

Simeoni L.

Cell Commun Signal. 2013 Jan 14

• Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and

LAX.

Arndt B, Kalinski T, Reinhold D, Thielitz A, Roessner A, Schraven B, Simeoni L.

J Leukoc Biol. 2013 Mar;93(3):353-62

• Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation.

Arndt B, Poltorak M, Kowtharapu BS, Reichardt P, Philipsen L, Lindquist JA, Schraven B,

Simeoni L. J Immunol Methods. 2013 Jan 31;387(1-2):76-83

• TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.

Warnecke N, Poltorak M, Kowtharapu BS, Arndt B, Stone JC, Schraven B, Simeoni L.

EMBO Rep. 2012 Apr;13(4):386-91

• The transmembrane adaptor protein SIT inhibits TCR-mediated signaling.

Arndt B, Krieger T, Kalinski T, Thielitz A, Reinhold D, Roessner A, Schraven B, Simeoni L.

PLoS One. 2011;6(9):e23761

• Treatment of inclusion body myositis: is low-dose intravenous immunoglobulin the solution?

Recher M, Sahrbacher U, Bremer J, Arndt B, Steiner U, Fontana A.

Rheumatol Int. 2012 Feb;32(2):469-72

• Control of lymphocyte development and activation by negative regulatory transmembrane

adapter proteins. Simeoni L, Lindquist JA, Smida M, Witte V, Arndt B, Schraven B.

Immunol Rev. 2008 Aug;224:215-28

• Regulation of T cell homeostasis by the transmembrane adaptor protein SIT.

Posevitz V, Arndt B, Krieger T, Warnecke N, Schraven B, Simeoni L.

J Immunol. 2008 Feb 1;180(3):1634-42.

• A logical model provides insights into T cell receptor signaling.

Saez-Rodriguez J, Simeoni L, Lindquist JA, Hemenway R, Bommhardt U, Arndt B, Haus UU,

Weismantel R, Gilles ED, Klamt S, Schraven B.

PLoS Comput Biol. 2007 Aug;3(8):e163

• Normal T-cell development and immune functions in TRIM-deficient mice.

Kölsch U, Arndt B, Reinhold D, Lindquist JA, Jüling N, Kliche S, Pfeffer K, Bruyns E, Schraven B,

Simeoni L.

Mol Cell Biol. 2006 May;26(9):3639-48